PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats
Addiction Biology October 2, 2007 Firas Kobeissy, Jennifer A. Jeung, Matthew Warren et al. 47 citations
Acute administration of MDMA (ecstasy) and methamphetamine to adult male rats altered serum levels of appetite-regulating hormones in a dose- and time-dependent manner. MDMA caused transient decreases in leptin and growth hormone and increases in ghrelin, with levels returning to baseline after 24 hours. Both MDMA and methamphetamine produced a steady decrease in neuropeptide-Y. These hormone changes may help explain the reduced eating observed in humans who abuse these drugs.