MDMA Induces Caspase‐3 Activation in the Limbic System but not in Striatum
Annals of the New York Academy of Sciences August 1, 2006 Ilaria Tamburini, Fabio Blandini, Marco Gesi et al. 24 citations
MDMA treatment activates caspase-3, an enzyme involved in cell death, in the amygdala and hippocampus of rodents, but not in the striatum or frontal cortex. This indicates that limbic brain structures are particularly sensitive to MDMA's potential to trigger apoptotic pathways, which may help explain memory loss and cognitive impairments observed in chronic MDMA users.