Micro-solid phase extraction coupled with high-performance liquid chromatography–tandem mass spectrometry for the determination of stimulants, hallucinogens, ketamine and phencyclidine in oral fluids
Analytica Chimica Acta July 23, 2010 Manuel Sergi, Darío Compagnone, Roberta Curini et al. 61 citations
A new method for detecting multiple illicit drugs in biological samples uses a modified fiberglass tip coated with octadecylsilane to extract drugs from the sample before analysis. The method can identify amphetamine, methamphetamine, MDMA, cocaine, benzoylecgonine, ketamine, mescaline, phencyclidine, psilocybine, and others. Quantification is done with liquid chromatography-tandem mass spectrometry. Detection limits range from 0.3 ng/mL for cocaine to 4.9 ng/mL for psilocybine, with all analytes showing coefficients of determination above 0.99, meeting forensic toxicology guidelines.