Nicolò Schifano

Department of Urology, ASST Sette Laghi-Ospedale di Circolo di Varese, 21100 Varese, Italy.

2 papers in the library · 14 citations · publishing 2025-2026

Papers

Drugs Used in "Chemsex"/Sexualized Drug Behaviour-Overview of the Related Clinical Psychopharmacological Issues.

Brain sciences April 22, 2025 Fabrizio Schifano, Stefania Bonaccorso, Davide Arillotta et al. 14 citations

Chemsex involves using drugs like synthetic cathinones, GHB/GBL, ketamine, methamphetamine, and others to enhance and prolong sexual experiences. Stimulants increase sexual arousal, performance, and social interactions; MDMA-like drugs foster emotional closeness; GHB/GBL promotes disinhibition, leading to condomless sex with multiple partners; ketamine facilitates receptive anal intercourse or fisting. Polydrug use can cause serotonergic syndrome, seizures, drug interactions, and sympathomimetic overstimulation, along with psychopathological conditions that may lead to misuse of opioids, gabapentinoids, or antipsychotics. Reducing stigma and providing multidisciplinary medical, psychological, and social support are key to managing these challenges.

DOI: 10.3390/brainsci15050424 Full text Substance abuse Sexual health Chemsex Drug addiction +4

Treatment and management approaches for ketamine misuse: A systematic review of medical interventions

Journal of Substance Use and Addiction Treatment July 1, 2026 Alessio Mosca, Stefania Chiappini, Andrea Miuli et al.

Management of ketamine misuse relies on supportive care, psychotherapy, and off-label medications, but robust evidence is lacking. A systematic review of 73 studies found that approaches include symptomatic medical care, psychotherapeutic interventions such as motivational interviewing and cognitive-behavioral therapy, and pharmacological treatments including benzodiazepines, SSRIs, naltrexone, lamotrigine, and gabapentinoids, with varying effectiveness. Multidisciplinary strategies addressing both psychiatric and somatic complications, such as 'K-bladder' and 'K-cramps', are essential. High relapse rates and limited follow-up weaken the evidence, and there is an urgent need for controlled studies and standardized treatment protocols.

DOI: 10.1016/j.josat.2026.210061 Ketamine Psychological intervention Medline Systematic review +2