Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies
Biological Psychiatry February 1, 2026 Jin Zhang, Cong Lin, Xinyou Lv et al. 1 citation
Psychedelics can significantly enhance neuroplasticity, as evidenced by a study involving 100 participants. Participants experienced a remarkable 40% increase in synaptic plasticity markers after treatment. The effects were linked to improved neurotransmission and elevated levels of neurotrophic factors, essential for brain health. Long-term potentiation was notably enhanced, indicating potential for cognitive benefits. Additionally, the involvement of nicotinic acetylcholine receptors suggests a complex interplay in metaplasticity. This research highlights the transformative potential of psychedelics in psychology and neuroscience, paving the way for innovative therapeutic approaches.