Lysergic acid diethylamide modulates hippocampal and cortical local field potential oscillatory rhythms in male mice
Brain Research January 2, 2026 B.s. Rabinovitch, N. Silverman, D. Ji et al.
Lysergic acid diethylamide (LSD) acutely reduces the power of electrical signals across multiple frequency bands in the hippocampus and, to a lesser extent, in the somatosensory and medial prefrontal cortices of freely-behaving male mice. The drug also increases variability in signal power between individual animals, suggesting effects that differ from one subject to another. These findings align with clinical neurophysiology data and support the entropic brain theory of psychedelic drug action. The study used intracranial EEG recordings to avoid the stress of physical restraint, providing the first such preclinical evidence of LSD's spectral signatures in freely-behaving mice.