Convergent effects of different anesthetics on changes in phase alignment of cortical oscillations.
Cell reports May 27, 2025 Alexandra G Bardon, Jesus J Ballesteros, Scott L Brincat et al. 8 citations
Two anesthetics with different molecular actions, ketamine and dexmedetomidine, both increase phase locking of neural oscillations in the prefrontal cortex of nonhuman primates during loss of responsiveness. Within a hemisphere, neighboring prefrontal subregions become less phase-aligned, possibly due to large traveling waves. However, homologous areas across hemispheres become more aligned in phase. These distinct patterns of cortical phase alignment, markedly different from waking states, may represent a common mechanism by which diverse anesthetics produce loss of responsiveness.