This narrative review, the first in a series on appropriate conduct in substance-assisted psychotherapy (SAPT), outlines preconditions and theoretical knowledge valuable for therapeutic practice. It discusses ethical considerations and the spiritual emphasis of SAPT approaches, and summarizes current methods, models, and concepts of psychological mechanisms and therapeutic effects. Similarities between models and potential mediators for therapeutic effects are highlighted. The review argues that the therapeutic effect of SAPT may be mediated by intra- and interpersonal variables within the therapeutic context rather than specific therapeutic models per se. It provides a basis for developing future investigations, therapeutic models, and training programs, while discussing limitations and future directions.
A systematized review of 82 sources examined best therapeutic practices during administration sessions with serotonergic psychedelics and entactogens as adjuncts to psychotherapy. Information about substances, dosages, number of sessions, common client issues, types of experiences, music, and therapeutic conduct was summarized and compared. The effects of different therapeutic models, methods, techniques, and complex interventions on outcomes have not been rigorously investigated. Most available evidence was anecdotal, limiting conclusive statements about appropriate therapeutic conduct. Essential components of therapeutic interventions remain largely tentative, necessitating systematic investigation.