The brain's code and its canonical computational motifs. From sensory cortex to the default mode network: A multi-scale model of brain function in health and disease
Neuroscience & Biobehavioral Reviews May 5, 2015 Federico Turkheimer, Robert Leech, Paul Expert et al. 64 citations
The brain appears to use repeated computational building blocks—canonical computational motifs—that are similar across species, brain areas, and sensory modalities. These motifs, grounded in stereotyped neuronal circuits and inhibitory interneurons, operate at micro-, meso-, and macro-scales to form a multiplexing information system capable of encoding and transmitting increasingly complex information. Similar activation patterns are observed in primary sensory cortices via electrophysiology and in large-scale networks measured with fMRI. The authors apply this canonical model to unify evidence on the pathophysiology of schizophrenia and suggest it may extend to other brain disorders involving GABA interneuron dysfunction.