Psilocybin-Induced Neuroplasticity and Sustained Antidepressant Effects
Quality in Sport January 31, 2026 Anna Maria Komarczewska, Filip Matusiak, Klaudia Brzoza et al.
Psilocybin-assisted interventions produce rapid reductions in depressive symptoms that can persist for months, including six-month outcomes in treatment-resistant depression protocols with psychological support. Convergent evidence from animal studies shows structural synaptic remodeling in frontal cortex and hippocampal plasticity changes in extinction learning paradigms. Human neuroimaging reveals altered large-scale brain dynamics after psilocybin. These findings support neuroplasticity as a biologically plausible mechanism linking transient serotonergic receptor activation to sustained clinical improvement.