A Randomised, Triple-Blind, Dose-Finding Study of the Impact of Psilocybin on Motor Function in Healthy Participants
medRxiv December 23, 2025 Chiranth Bhagavan, O. Carter, Glenn Nielsen et al. 1 citation
Movement tasks such as walking, reaching, and dexterity tests were feasible for healthy volunteers who took psilocybin doses up to 15 mg. At 20 mg, impairments appeared in tasks that combined movement with cognitive demands, such as the Box and Block Test and Digit Symbol Substitution Test. Nausea (62% of participants) and headache (54%) were the most common adverse events; no serious adverse events occurred. Participants and physiotherapists guessed the dose correctly only about half the time, indicating adequate blinding. These results suggest that psilocybin-assisted physical rehabilitation may be safe and feasible for future trials in people with movement disorders.