THE PSYCHEDELIC RENAISSANCE: A SYSTEMATIC REVIEW OF PSILOCYBIN AND LSD IN THE TREATMENT OF PSYCHIATRIC DISORDERS
International Journal of Innovative Technologies in Social Science January 23, 2026 Jakub Klepacz, Radosław Swędrak, Marzena Swojnóg et al.
Classical serotonergic hallucinogens like psilocybin and LSD are being re-evaluated in clinical research. A systematic review traces their history from indigenous use through prohibition to current trials. The compounds act via 5-HT2A receptor agonism and disrupt the Default Mode Network, which may help alleviate rigid cognitive patterns in depression and anxiety. Clinical data show significant therapeutic potential for Treatment-Resistant Depression, end-of-life distress, and substance use disorders. The review emphasizes that psychedelic-assisted therapy requires a specific psychotherapeutic framework, integration processes, and attention to cost-effectiveness and access equity. This approach suggests a shift from chronic symptom management to rapid, episodic curative interventions if regulatory and ethical challenges are addressed.