Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors
Neuropsychopharmacology November 27, 2018 Hanna J. Szkudlarek, Sagar Desai, Justine Renard et al. 63 citations
Acute infusions of THC directly into the prefrontal cortex of rats produce anxiety-like effects without impairing executive function, while CBD infusions impair attentional set-shifting and spatial working memory without affecting anxiety or sociability. CBD reverses cognitive impairments caused by glutamatergic antagonism in the prefrontal cortex and blocks the anxiety-inducing properties of THC, suggesting CBD's therapeutic effects may only emerge during pathological states. These opposing effects are mediated through dissociable CB1 and 5-HT1A receptor signaling mechanisms within the prefrontal cortex.