Aspectos Farmacológicos e Toxicológicos do Alcaloide N, N – Dimetiltriptamina (DMT)
Brazilian Journal of Natural Sciences March 11, 2020 Lilian Carvalho Machado, Renan Honorato Da Cruz, Soraia Sayuri Higa et al. 3 citations
DMT, an alkaloid found in Psychotria viridis leaves used in ayahuasca tea, acts as an agonist at serotonin receptors 5-HT1A, 5-HT2A, and 5-HT2C, causing nausea, tremors, mood changes, and reports suggest immune alterations via decreased CD3 and CD4 lymphocyte levels. Recent in vivo tests indicate potential antitumor, antidepressant, and anxiolytic therapeutic effects, as well as aid in treating alcoholism and tobacco addiction. The review describes DMT's pharmacological and toxicological effects, concluding it has pharmacological potential but also significant adverse effects and toxicity, warranting further acute and chronic tests and epidemiological research on populations using it.