Effects of acute social stress on the conditioned place preference induced by MDMA in adolescent and adult mice
Behavioural Pharmacology September 1, 2014 María Pilar García-pardo, Marta Rodrı́guez-arias, Concepción Maldonado et al. 29 citations
Social defeat stress reduces the rewarding effects of MDMA in adult male mice, but not in adolescents. Adult mice exposed to social defeat before each MDMA conditioning session did not develop a conditioned place preference at either 1.25 or 10 mg/kg doses, indicating decreased sensitivity to MDMA reward. Social defeat did not alter the motor or anxiogenic effects of MDMA. Adult defeated mice had higher corticosterone levels than controls and adolescent mice. Social stress had no behavioral effects in adolescent mice, suggesting age-dependent vulnerability.