Efficacy of Intravenous Racemic Ketamine on Global Severity and Individual Symptoms of Depression
Journal of Clinical Psychopharmacology September 25, 2025 Rachel Landrum, Amanda M. Raines, Philip D. Harvey et al. 1 citation
Maintenance intravenous racemic ketamine therapy produced significant, persistent, and broad symptom relief for treatment-resistant depression. Reductions occurred in both clinician-rated (Montgomery-Åsberg Depression Rating Scale) and patient-reported (Patient-Health Questionnaire-9) depression scores. Changes in individual symptoms were similar to prior trials: suicidal ideation and depressed mood improved most, while appetite disturbance improved least.