Azzurra Martini

Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo

2 papers in the library · 7 citations · publishing 2026

Papers

Integrating Psychiatric, Psychotherapeutic, and Nursing Care in Intranasal Esketamine for Treatment-Resistant Depression

Journal of Clinical Medicine February 20, 2026 Vassilis Martiadis, Fabiola Raffone, Serena Testa et al. 7 citations

Intranasal esketamine provides rapid symptom relief for treatment-resistant depression when standard antidepressants fail, but its real-world effectiveness depends on organizational and multidisciplinary factors beyond pharmacology. This narrative review synthesizes clinical and real-world evidence to propose a phase-based integration framework that specifies complementary roles for psychiatry, nursing, and psychotherapy across pre-treatment assessment, induction, session delivery, post-session integration, and maintenance phases. The framework emphasizes safety, continuity of care, and patient-centred monitoring, with measurable implementation indicators. While evidence supports esketamine's efficacy in reducing depressive symptoms, anhedonia, and suicidality, prospective implementation studies are needed to evaluate clinical effectiveness, feasibility, and cost-effectiveness of the proposed multidisciplinary approach.

DOI: 10.3390/jcm15041629 Major depressive disorder Treatment-resistant depression Anhedonia Multidisciplinary approach +11

Toward Integrating Intranasal Esketamine with Traumatic-Memory Psychotherapy in Treatment-Resistant Depression: A Narrative Review and Feasibility-Oriented Protocol Proposal.

Behavioral sciences (Basel, Switzerland) May 14, 2026 Fabiola Raffone, Carlo Ignazio Cattaneo, Enrico Pessina et al.

Trauma-related autobiographical memories can become intrusive and distressing, contributing to post-traumatic stress disorder (PTSD) and depression, including treatment-resistant depression (TRD). Intranasal esketamine, an approved rapid-acting treatment for TRD, may create conditions that facilitate psychotherapeutic work on traumatic memories. This narrative review synthesizes evidence on ketamine and esketamine for PTSD and trauma symptoms, distinguishing intravenous ketamine studies, intranasal esketamine data, and combination approaches with psychotherapy.

DOI: 10.3390/bs16050771 Full text Esketamine Post-traumatic stress disorder Treatment-resistant depression Imagery rescripting +5