A trip through the psychiatric use of psychedelics in Brazil: A scoping review
Psychedelics May 30, 2026 Vinicius Ryu Kami, Beatriz Borges Bueno Salle, Giovanni Porto et al.
A scoping review mapped Brazilian research on psychedelics for psychiatric disorders, identifying 18 studies with 831 participants. Most research focused on Ayahuasca (13 studies), followed by Ibogaine and DMT. Key findings suggest rapid antidepressant effects of Ayahuasca and vaporized DMT, while Ibogaine showed potential for extending abstinence in substance use disorders. Limitations include small sample sizes, regional centralization of research (primarily in São Paulo and Rio Grande do Norte), and challenges regarding functional unblinding. The review concludes that Brazilian scientific production connects traditional Ayahuasca practices with clinical research, but future studies need larger multicentric trials and more rigorous blinding strategies.