David S. Galstyan

2 papers in the library · 20 citations · publishing 2022

Papers

Acute behavioral and Neurochemical Effects of Novel N -Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish

ACS Chemical Neuroscience June 7, 2022 Konstantin A. Demin, Olga V. Kupriyanova, Вадим А. Шевырин et al. 20 citations

Novel N-benzyl-2-phenylethylamine (NBPEA) derivatives, with specific substitutions in the N-benzyl and phenethylamine moieties, alter locomotion and anxiety-like behavior in adult zebrafish. Substitutions in the N-benzyl moiety modulate locomotion, while those in the phenethylamine moiety affect anxiety-like behavior and brain serotonin or dopamine turnover. The 24H–NBOMe(F) and 34H–NBOMe(F) treatments reduced despair-like behavior. Computational analyses classified the agents into anxiogenic/hypolocomotor, behaviorally inert, anxiogenic/hallucinogenic-like, and anxiolytic/hallucinogenic-like clusters, with some NBPEAs showing behavioral similarity to conventional serotonergic and antiglutamatergic hallucinogens. These findings suggest potent neuroactive properties of several NBPEAs, indicating potential clinical use or abuse.

DOI: 10.1021/acschemneuro.2c00123 Full text Serotonergic Mescaline Serotonin Neurochemical +13

Behavioral and neurochemical effects of novel N-Benzyl-2-phenylethylamine derivatives in adult zebrafish

bioRxiv (Cold Spring Harbor Laboratory) January 21, 2022 Konstantin A. Demin, Olga V. Kupriyanova, Вадим А. Шевырин et al. preprint

Certain synthetic N-Benzyl-2-phenylethylamine (NBPEA) derivatives, related to hallucinogens like mescaline and MDMA, produce distinct behavioral and neurochemical effects in adult zebrafish. Substitutions on the N-benzyl fragment primarily affected locomotion, while those on the phenethylamine moiety influenced anxiety-like behavior. The compounds also modulated brain serotonin and/or dopamine turnover. Several behavioral clusters emerged: anxiogenic/hypolocomotor, behaviorally inert, anxiogenic/hallucinogenic-like, and anxiolytic/hallucinogenic-like. Two compounds reduced despair-like behavior. Artificial intelligence-driven phenotyping linked multiple compounds to NMDA antagonists and/or MDMA, suggesting hallucinogenic-like properties. In silico modeling indicated similarities between these NBPEAs, MDMA, and ketamine, implicating serotonin release, calcium channel activity, and serotonin receptor involvement.

DOI: 10.1101/2022.01.19.476767 Serotonergic Mescaline MDMA Serotonin +14