Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation
PLoS ONE April 21, 2017 Emilia M. Lefevre, Gregory Medley, Timothy Reeks et al. 8 citations
Co-administration of the glucocorticoid receptor antagonist RU486 with the NMDA receptor antagonist MK-801 in male Sprague Dawley rats unexpectedly enhanced rather than blocked the development of locomotor sensitisation. Both RU486 and MK-801 individually raised plasma corticosterone levels, and the combination further increased them. RU486 also elevated dopamine, DOPAC, and HVA in nucleus accumbens tissue. The findings indicate that glucocorticoids play a divergent role in sensitisation to MK-801 compared to other psychostimulants.