The Use of Psilocybin in the Treatment of Depressive Disorders: A Narrative Review
Cureus January 31, 2026 Lukasz Siwek, Marta Nowocien, Barbara Balajewicz et al.
Psilocybin, a psychoactive compound from Psilocybe mushrooms that activates serotonergic receptors, is being investigated as a treatment for depression, a psychiatric disorder with rising global prevalence projected to become the leading cause of disability by 2030. This narrative review presents recent reports on psilocybin-assisted therapy, which, based on promising results showing higher therapeutic efficacy compared to conventional treatments, offers hope for a modern approach with sustained clinical effects and minimal or no adverse effects.