The 50% effective dose of remimazolam combined with different doses of esketamine for painless gastroscopy.
Scientific reports April 14, 2025 Li Zhao, Xuelei Zhou, Linlin Chen et al. 5 citations
Adding esketamine to remimazolam for sedation during painless gastroscopy reduces the required dose of remimazolam and improves hemodynamic stability. In a randomized double-blind study, the median effective dose (ED50) of remimazolam alone was 0.344 mg/kg, which fell to 0.289 mg/kg with 0.2 mg/kg esketamine and to 0.193 mg/kg with 0.4 mg/kg esketamine. Patients receiving esketamine had more stable blood pressure and less hypotension, but their recovery times were significantly longer. The combination offers advantages in safety and stability for endoscopic sedation.