The suitability of zebrafish (danio rerio) as an optimal organism to further investigate the associated schizophrenia-like phenotype
European Psychiatry October 23, 2023 I. B. Nita, O. D. Ilie, A. S. Ciobica et al.
A review of 246 studies from 2010 to 2022 examined how various substances induce schizophrenia-like symptoms in zebrafish. The compounds included NMDA inhibitors (MK-801, ketamine, phencyclidine), psychedelics (mescaline, LSD), amphetamine, and amino acids (proline, methionine). Most research focused on MK-801, ketamine, amphetamine, proline, methionine, and phencyclidine, with fewer studies on mescaline and LSD. Findings were inconsistent, showing both increases and decreases in behaviors such as locomotion, aggression, sociability, circling, and memory. The authors conclude that additional studies are needed to clarify these effects and guide future research on pharmacodynamics and kinetics.