Prolonged blockade of NMDA receptors and positive modulation of a5 GABA A receptors: No changes in depressive-like behavior, while the former slightly increased emotional reactivity in unstressed rats
Medicinska istrazivanja January 1, 2025 Djordje Djorović, Jana Ivanović, Kristina Jezdić et al.
Repeated administration of ketamine (an NMDA receptor antagonist) and GL-II-73 (a positive modulator of a5GABA A receptors) over seven days in adult male rats produced no changes in behavioral despair (forced swim test) or anxiety-like behavior (novelty suppressed feeding test). In spontaneous locomotor activity tests, all treatments reduced the percentage of time spent in the central area at 10 and 30 minutes. Only the higher 10 mg/kg dose of ketamine also reduced central distance traveled at both time points, suggesting a slight increase in emotional reactivity. The lower dose of ketamine and GL-II-73 produced minor changes of similar quality, hardly indicating an anxiety-inducing effect.