Change in Negative Affective Bias following a Single Ketamine Treatment for Treatment-Resistant Depression
Depression and Anxiety August 19, 2023 Anna J. Harvey, Stevan Nikolin, Nicholas Chand et al. 4 citations
A single dose of ketamine, compared to an active control (midazolam), did not produce significant changes in most measures of emotional or cognitive processing in people with treatment-resistant depression one day after treatment. However, participants who received ketamine showed a significant improvement on a test of negative processing bias, though this improvement was not significantly linked to changes in depressive symptoms. The study was small and exploratory, and larger trials are needed to confirm the finding.