MODERN STRATEGIES FOR THE TREATMENT OF TREATMENT-RESISTANT DEPRESSION – A LITERATURE REVIEW
International Journal of Innovative Technologies in Social Science September 30, 2025 Ignacy Rożek, Wojciech Gąska, Izabela Lekan et al.
Treatment-resistant depression affects many people with major depressive disorder who do not achieve remission with standard antidepressants. This review examines current and emerging strategies, including medication combinations, neuromodulation, and psychedelic-assisted therapies. Ketamine, esketamine, and psilocybin show promise for non-responders. Future approaches may repurpose drugs like lurasidone, pioglitazone, and minocycline for new mechanisms and better tolerability. A personalized, evidence-based, multidimensional treatment plan is emphasized to improve short-term response and long-term recovery.