Ketamine Reverses Chronic Stress‐Induced Behavioral Changes via the Expression of Ca 2+ ‐Permeable AMPA Receptors in Mice
The FASEB Journal August 26, 2025 Joshua C. Flowers, Paige E. Vetter, McKennon J. Wiles et al. 7 citations
Low-dose ketamine rapidly induces the expression of calcium-permeable AMPA receptors (CP-AMPARs) in the hippocampus, which enhances glutamatergic synaptic strength. In mice subjected to chronic restraint stress, low-dose ketamine reverses social dysfunction, loss of hippocampus-dependent fear learning and memory, and depression-like behavior in both females and males. These antistress effects depend on CP-AMPAR expression. The findings suggest that subanesthetic low-dose ketamine triggers CP-AMPAR expression in the hippocampus, producing antidepressant and antistress effects.