Prolonged ketamine therapy differentially rescues psychobehavioural deficits via modulation of nitro-oxidative stress and oxytocin receptors in the gut-brain-axis of chronically-stressed mice.
Psychoneuroendocrinology December 1, 2023 Edem Ekpenyong Edem, Oluwatomisn Adeyosola Oguntala, Daniel Akinwale Ikuelogbon et al. 4 citations
Prolonged treatment with ketamine did not alleviate depressive-like behavior in female mice exposed to chronic unpredictable mild stress, but it did improve anxiety-like behaviors, short-term memory, and social interaction deficits. Ketamine also increased plasma oxytocin levels and oxytocin receptor expression while reducing nitro-oxidative stress markers in intestinal and hippocampal tissues. These results suggest that although short-term ketamine has antidepressant effects, its extended use does not adequately resolve depressive-like behavior in mice.