Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.
Neurobiology of stress January 1, 2022 Zhuoyu Ren, Mingling Wang, Mokhtar Aldhabi et al. 28 citations
A single low dose of S-ketamine reduces depression- and anxiety-like behaviors in a rat model of postpartum depression (PPD) created by reproductive hormone withdrawal. The treatment also preserves synaptic plasticity in the hippocampus, as shown by molecular, structural, and electrophysiological measures. The findings suggest that maintaining synaptic plasticity is a key mechanism for S-ketamine's antidepressant effects in this PPD model.