Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis.
Journal of psychiatric practice November 1, 2015 Ajay K Parsaik, Balwinder Singh, Darrow Khosh-Chashm et al. 42 citations
A single intravenous dose of ketamine significantly reduces symptoms of treatment-resistant bipolar depression compared with placebo, with maximum improvement observed 40 minutes after infusion. The meta-analysis of three randomized controlled trials (69 subjects) showed a large effect (standardized mean difference -1.01). No serious side effects occurred, and side effects were similar between ketamine and placebo. Individual studies also reported reduced anhedonia and suicidal ideation after ketamine therapy.