Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe.
Chemistry (Weinheim an der Bergstrasse, Germany) March 2, 2020 Eva Garrido, María Alfonso, Borja Díaz de Greñu et al. 19 citations
A hybrid nanodevice based on mesoporous silica nanoparticles loaded with a fluorescent dye and capped with a 5-HT2A receptor antibody can detect the potent hallucinogenic drug 25I-NBOMe. When the drug is present, it displaces the antibody, opening pores and releasing rhodamine B, producing a fluorescent signal. The device achieves a detection limit of 0.6 μm and is selective for 25I-NBOMe over cocaine, heroin, mescaline, LSD, MDMA, and morphine. It works in artificial saliva and in sweets, acting as a sensitive and selective fluorometric probe for the illicit drug.