Personalized stimulation therapies for disorders of consciousness: a computational approach to inducing healthy-like brain activity based on neural field theory.
Journal of neural engineering June 10, 2025 Daniel Polyakov, P A Robinson, Eli J Müller et al. 2 citations
A computational method uses a simplified brain model fitted to a patient's EEG power spectrum to design personalized electrical stimulation signals. In computer simulations, these signals induce healthy-like brain activity patterns in models of people with disorders of consciousness. When the model's parameters were near a stability boundary, stimulation caused a lasting change in activity beyond the stimulation period. The approach may activate plasticity mechanisms during long-term treatment, potentially leading to sustained improvements. Further clinical adjustments and validation are needed, but the method holds promise for improving therapeutic outcomes in disorders of consciousness and may extend to other neurological conditions.