Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.
Psychopharmacology June 1, 2009 Matthew R Skelton, Tori L Schaefer, Nicole R Herring et al. 31 citations
Treating young rats with either MDMA or the club drug 5-MeO-DIPT from postnatal days 11 to 20 caused lasting cognitive and behavioral changes, but the patterns differed between the two drugs. MDMA-treated animals showed increased anxiety, deficits in spatial and path integration learning, and memory problems. 5-MeO-DIPT-treated animals had spatial learning deficits but no impairments in spatial memory or path integration learning, and they were hyperactive when given a challenge dose of methamphetamine. The findings indicate that developmental exposure to either drug produces distinct behavioral effects.