5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter.
Toxicology letters April 5, 2007 C Sogawa, N Sogawa, J Tagawa et al. 47 citations
5-MeO-DIPT, a synthetic hallucinogenic tryptamine, acts as a competitive inhibitor of the serotonin transporter (SERT), blocking serotonin uptake with high affinity and at concentrations similar to cocaine. It does not stimulate reverse transport of serotonin through SERT, and it prevents the serotonin-releasing action of methamphetamine. At high concentrations, the compound is toxic to cells, but this toxicity is not influenced by SERT expression. These findings clarify the serotonergic mechanism of 5-MeO-DIPT.