Joung-Wook Seo - Mindscape Collective

5-Methoxy-α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.

Behavioural brain research February 1, 2019 Arvie Abiero, Chrislean Jun Botanas, Leandro Val Sayson et al. 17 citations

5-MeO-AMT, a tryptamine used recreationally for its hallucinogenic and mood-elevating effects, triggers head-twitch response (HTR) in mice through activation of serotonin receptor 2a (5-HTR2a) in the prefrontal cortex. Acute administration at doses 0.3–10 mg/kg produced HTR, but repeated dosing led to tolerance. The 5-HTR2a antagonist ketanserin blocked the response. The drug increased 5-HTR2a mRNA and induced PKC-γ phosphorylation in the prefrontal cortex. 5-MeO-AMT did not produce locomotor sensitization, conditioned place preference, or self-administration, suggesting low abuse potential.

DOI: 10.1016/j.bbr.2018.07.020 Full text 5-methoxy-a-methyltryptamine Conditioned place preference Head-twitch response Self-administration +1

The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents.

International journal of molecular sciences June 29, 2020 In Soo Ryu, Oc-Hee Kim, Young Eun Lee et al.

The designer drug 4'-F-PCP, a derivative of the dissociative anesthetic phencyclidine (PCP), shows a high potential for abuse. In rodents, a 10 mg/kg dose increased movement and rearing, and produced conditioned place preference, indicating rewarding effects. Intravenous self-administration of 1.0 mg/kg/infusion was robust, with a higher breakpoint under progressive ratio schedules, suggesting strong reinforcing properties. The drug altered dopamine transporter and D1 receptor expression in the nucleus accumbens and increased phosphorylated ERK, CREB, c-Fos, and FosB/ΔFosB, indicating activation of dopamine-related signaling pathways. These findings indicate that 4'-F-PCP has significant abuse liability.

DOI: 10.3390/ijms21134631 Full text Abuse potential Conditioned place preference Designer drugs Phencyclidine pcp derivatives +1

4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels.

Psychopharmacology March 1, 2020 Arvie Abiero, Chrislean Jun Botanas, Raly James Custodio et al.

Two synthetic dissociative drugs, 4-MeO-PCP and 3-MeO-PCMo, produce rewarding and reinforcing effects in rats, indicating potential for abuse in humans. Both drugs induced conditioned place preference and self-administration, but only 4-MeO-PCP caused locomotor sensitization. Blocking dopamine D1 or D2 receptors prevented the drugs' rewarding effects. The drugs altered dopamine-related proteins and increased delta and gamma brain wave activity, effects also blocked by dopamine antagonists. These findings suggest the drugs' abuse potential is mediated through the mesolimbic dopamine system.

DOI: 10.1007/s00213-019-05412-y Full text 3-meo-pcmo 4-meo-pcp Abuse potential Dopaminergic system +2

Papers

5-Methoxy-α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.

The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4'-F-PCP) in Rodents.

4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels.