Lysergic acid diethylamide stimulates cardiac human H 2 histamine receptors
Research Square Ulrich Gergs, Hannes Jacob, Pauline Braekow et al. 1 citation
LSD increases the force and rate of heart muscle contraction by activating H2-histamine receptors in humans, and also acts as a partial agonist at 5-HT4 serotonin receptors in mice. In human atrial tissue from heart surgery patients, LSD's contractile effects were blocked by cimetidine, an H2-receptor antagonist. These findings clarify the cardiac effects of LSD, which is being studied again for psychiatric uses.