MDMA to Treat PTSD in Adults
Psychopharmacology Bulletin August 12, 2025 Dustin Latimer, Michael D. Stocker, Kia Sayers et al. 10 citations
Post-traumatic stress disorder (PTSD) is common among U.S. veterans. Standard treatments include trauma-focused psychotherapies and antidepressant medications such as SSRIs and SNRIs. MDMA, a psychoactive compound classified as a Schedule I controlled substance since the 1980s, has reemerged as a potential therapy. Before prohibition, psychotherapists used it for various psychiatric conditions. Recent randomized, controlled trials support MDMA as an effective pharmacological adjunct to psychotherapy for PTSD.