Anomalous self-experiences in biotypes of psychosis
European Archives of Psychiatry and Clinical Neuroscience June 5, 2026 Luis Sobrino-Conde, Antonio Arjona, Emma Osorio-Iriarte et al.
People with psychosis can be grouped into biotypes based on underlying pathological features rather than traditional diagnostic categories. One biotype (cluster 1) involves severe cognitive deficits, while another (cluster 2) involves moderate cognitive deficits. In a study of 113 patients, those in cluster 1 reported significantly more anomalous self-experiences—disturbances in the sense of self—than both healthy controls and cluster 2 patients. Cluster 2 patients showed only slight differences from controls. These findings suggest that severe disruptions in self-experience are a key feature of the biotype characterized by marked cognitive impairment, brain structure changes, and higher negative symptoms.