Microdoses de psicodélicos no tratamento de transtornos mentais: uma revisão sistemática
Revista Científica Multidisciplinar Núcleo do Conhecimento May 9, 2025 Gabriel Jorge Cascaes Santos Cavalcante, Amanda Thaís Magrini, Roberto Heck Rigelli et al.
Microdosing psychedelics—taking a fraction of a recreational dose to avoid hallucinogenic effects—is associated with perceived improvements in creativity, focus, well-being, and symptoms of anxiety, depression, and attention-deficit/hyperactivity disorder. However, these benefits appear tied to the drug's acute effects, and some users report unwanted hyperstimulation, hallucinogenic effects, worsened anxiety, and emergence of negative emotions. Few randomized controlled trials have evaluated microdosing; much evidence comes from online self-reports, limiting objectivity. Preliminary findings suggest possible efficacy for mental disorders, but larger controlled studies are needed to establish safety and definitive conclusions.