Psychedelics and neurostimulation for treatment resistant psychiatric disorders.
Discover mental health May 25, 2026 Filip Blazek, Klara Latalova, David Krahulik et al.
Psychedelic-assisted therapy and neurostimulation both aim to alter malfunctioning brain circuits in treatment-resistant psychiatric conditions. This Perspective identifies overlapping mechanisms—neuroplasticity and network reconfiguration—that underlie both approaches. It also considers ethical, regulatory, and practical obstacles to bringing these treatments into clinical use. By connecting neuroscience, psychiatry, and policy, the authors suggest ways to incorporate these novel interventions into evidence-based, circuit-oriented mental health care.