Protective effects of vitamin E and quercetin against MDMA-induced cardiac and hematological dysfunction in male wistar rats.
Pflugers Archiv : European journal of physiology April 23, 2026 Ayodeji Folorunsho Ajayi, David Tolulope Oluwole, Moses Agbomhere Hamed et al.
In adult male Wistar rats, the recreational drug MDMA (ecstasy) caused heart damage, oxidative stress, inflammation, abnormal blood lipids, and disrupted blood cell counts. The antioxidants quercetin and vitamin E, given separately, each reduced these harmful effects. When given together, quercetin and vitamin E provided the greatest protection, nearly restoring normal heart tissue, blood chemistry, and blood cell levels. Neither antioxidant alone altered normal rats' baseline measurements. The combined treatment suggests a potential approach for mitigating MDMA-related heart and blood toxicity.