Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in the prefrontal cortex, amygdala, and hippocampus of Sprague-Dawley rats
IBRO Reports January 16, 2019 Michael Zhang, Kennett D. Radford, Mercedes Y. Driscoll et al. 34 citations
A single intravenous infusion of ketamine in rats produces dose-dependent and brain region-specific changes in proteins linked to neural plasticity. A high dose (40 mg/kg) increased c-Fos in the medial prefrontal cortex and amygdala, and increased pERK in the medial prefrontal cortex and hippocampus. A low dose (10 mg/kg) increased BDNF in the amygdala but decreased pERK in the medial prefrontal cortex and hippocampus. These results suggest that the route and dose of ketamine administration matter for its effects on neuroplasticity-related proteins.