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Jean Théberge

Psychiatry, Western University, 1151 Richmond Street, London, Ontario, Canada N6A 3K7; Medical Imaging, Western University, 1151 Richmond Street, London, Ontario, Canada N6A 3K7; Medical Biophysics, Western University, 1151 Richmond Street, London, Ontario, Canada N6A 3K7; Imaging Division, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2; Department of Diagnostic Imaging, St. Joseph's Healthcare, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2.

1 paper in the library · 64 citations · publishing 2017

Papers

Sensory overload and imbalance: Resting-state vestibular connectivity in PTSD and its dissociative subtype.

Neuropsychologia November 1, 2017 Sherain Harricharan, Andrew A Nicholson, Maria Densmore et al. 64 citations

People with posttraumatic stress disorder (PTSD) and its dissociative subtype show altered brain connectivity between the vestibular system—which integrates sensory information about body orientation—and cortical regions involved in self-awareness. Using resting-state fMRI, researchers compared 60 people with PTSD, 41 with the dissociative subtype, and 40 healthy controls. The PTSD and control groups had stronger connectivity between the vestibular nuclei and the parieto-insular vestibular cortex and dorsolateral prefrontal cortex than the dissociative subtype group. Greater depersonalization and derealization symptoms correlated with weaker connectivity in the right supramarginal gyrus. These findings suggest that disrupted vestibular multisensory integration may contribute to distinct symptom profiles in PTSD and its dissociative subtype.

DOI: 10.1016/j.neuropsychologia.2017.09.010 Full text Depersonalization Hypervigilance Interoception Parieto-insular vestibular cortex +2