Locomotor and Reinforcing Effects of Pentedrone, Pentylone and Methylone in Rats
bioRxiv Preprint Server July 21, 2017 Mehrak Javadi-Paydar, Jacques D. Nguyen, Sophia A. Vandewater et al. 7 citations preprint
Second generation synthetic cathinones pentedrone and pentylone produce dose-dependent increases in locomotion in male and female Wistar rats, with the maximum effect similar across drugs but lasting longest after pentedrone. Body temperature remained stable after pentedrone or pentylone, while methylone caused sustained hyperthermia in male rats. Rats self-administered more pentedrone or pentylone than methylone, but all three were less potent than α-PVP or α-PHP. These results suggest that pentedrone and pentylone have greater abuse liability than methylone.