A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.
Npj Ment Health Res July 2, 2024 Ronit Kishon, Nadav Liam Modlin, Yael M. Cycowicz et al. 22 citations
Before psychedelics were prohibited, clinical research with complex psychiatric patients developed diverse treatment methods and practices that remain relevant today. These early studies, though lacking modern rigor, recognized that the treatment context and clinician's role are essential for positive outcomes. This review examines pre-prohibition clinical narratives about the phenomenology of psychedelic treatment and non-pharmacological factors in patient experience. It also explores clinician perspectives and psychological interventions from that era to inform future research directions and best practice guidelines for modern psychedelic research and clinician training.