An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression.
Front Psychiatry November 24, 2021 Sherry-Anne Muscat, Glenn Hartelius, Courtenay Richards Crouch et al. 47 citations
An integrative approach that combines ketamine therapy with supportive psychotherapy may enhance treatment outcomes for people with treatment-resistant depression. The authors argue that ketamine's rapid antidepressant effects can be optimized when paired with psychological interventions that help patients process and integrate the drug-induced experiences. This combined strategy may address multiple dimensions of depression, including mood, cognition, and interpersonal functioning, potentially leading to more durable therapeutic benefits than ketamine alone. The paper suggests that integrating pharmacological and psychotherapeutic modalities could improve the overall efficacy of treatment for severe depression.