LSD-induced entropic brain activity predicts subsequent personality change.
Hum Brain Mapp May 6, 2016 A.V. Lebedev, M. Kaelen, M. Lövdén et al. 333 citations
A single dose of LSD increased brain entropy—the unpredictability of neural activity—across sensory and higher-order networks in 19 healthy adults. These entropy shifts, measured during resting-state fMRI, predicted lasting increases in the personality trait openness two weeks later. The predictive effect was strongest when participants listened to music and reported experiences of ego dissolution during the drug's acute effects. The findings suggest that psychedelic-induced changes in brain dynamics and subjective experience can forecast enduring personality change.