Locomotor and discriminative stimulus effects of NBOH hallucinogens in rodents.
Behav Pharmacol December 6, 2024 Daaniyal D. Munir, Ritu A. Shetty, Michael B. Gatch et al. 1 citation
Four novel synthetic hallucinogens structurally similar to 25X-NBOMe compounds—25B-NBOH, 25C-NBOH, 25E-NBOH, and 25I-NBOH—were tested in mice and rats. All four decreased spontaneous locomotor activity in mice, with effects similar in magnitude and potency to the hallucinogen DOM but less potent than 25X-NBOMe compounds. In rats trained to discriminate DOM, 25B-NBOH, 25C-NBOH, and 25E-NBOH fully substituted for DOM, indicating they produce similar psychoactive effects, while 25I-NBOH failed to fully substitute even at doses that suppressed responding. The findings suggest three of the four compounds are likely to be used recreationally as hallucinogens, whereas 25I-NBOH may have lower abuse liability.