Subanaesthetic ketamine and altered states of consciousness in humans
British Journal of Anaesthesia April 13, 2018 Phillip E. Vlisides, Tarik Bel‐bahar, Amanda Nelson et al. 117 citations
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Paul Picton
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI 48109, United States; Michigan Psychedelic Center, University of Michigan Medical School, Ann Arbor, MI 48109, United States.
2 papers in the library · 166 citations · publishing 2018-2023
Papers
Classical and non-classical psychedelic drugs induce common network changes in human cortex.
NeuroImage June 1, 2023 Rui Dai, Tony E Larkin, Zirui Huang et al. 49 citations
Three different psychedelics—nitrous oxide, ketamine, and lysergic acid diethylamide—produce a common pattern of brain network changes despite having distinct molecular mechanisms and delivery methods. Each drug reduced connectivity within brain networks and enhanced connectivity between networks. Specifically, all three increased connections between the right temporoparietal junction and bilateral intraparietal sulcus, and between the precuneus and left intraparietal sulcus. These regions lie within the posterior cortical "hot zone," an area thought to mediate the qualitative aspects of experience. The findings identify a biologically plausible candidate for the subjective effects of both classical and non-classical psychedelics.