Age-related alterations in default mode network: Impact on working memory performance
Neurobiology of Aging August 1, 2008 Fabio Sambataro, Vishnu P. Murty, Joseph H. Callicott et al. 534 citations
Normal aging reduces the ability to suppress low-frequency oscillations and decreases functional connectivity within the default mode network (DMN) during a working memory task. Older adults showed weaker coupling between the posterior cingulate and medial prefrontal cortex, and this coupling strength correlated positively with performance. The posterior cingulate was also negatively coupled with task-related regions like the dorsolateral prefrontal cortex and cingulate. These changes may reflect a deficit in cognitive control that impairs resource allocation to the task.